The physics of the heart is a bit simple at first glance - the
heart exerts a force that causes the blood to flow through blood
vessels and causes a measurable pressure (blood pressure) on them.
Blood pressure changes with volume, when the blood vessels dilate (more
volume) blood pressure goes does; when blood vessels constrict (less
volume) blood pressure goes up.
Physics is used in nuclear cardiology to help pinpoint the cause of a
patient's chest pain without having to do more invasive procedures.
Using nuclear imaging one can see the blood flow to the heart non
invasively. Looking at the change in volume allows us to figure out the
change in pressure and see if something more invasive needs to be done
in order to remedy the lack of blood flow.